Preheat the oven 300ºF and boil enough water for water bath.
Place the milk and cream in a saucepan.
Split the vanilla bean in half lengthwise, scrape the seeds and add to the milk and cream along with the pod.
Bring to a boil over medium heat. Remove from the burner and let infuse the flavor.
In a large bowl, mix in the sugar at once over the egg yolks, whisking until light yellow color. About 2 min.
Pour about ⅓ of the hot milk and cream into the yolks for tempering. Pour in all liquid until combined.
Strain the custard mixture through a fine mesh sieve into a large measuring cup.
Divide custard mixture evenly filling about 2/3 up the sides of the ramekins.
Place the dishtowel on the roasting pan. Arrange the ramekins onto it to prevent them from slipping on the baking sheet.
Place into the oven adn fill with hot water until halfway up the sides of ramekins.
Cook for about 30 min or until almost fully set with a somewhat steady center.
Remove from the oven and transfer the ramekins to a tray. Let cool down for about 1 hour.
Cover the ramekins with plastic wrap. Chill in the fridge for at least 3 hr or up to 2 days.